We have previously demonstrated that subsets of Ssn6/Tup target genes have distinct requirements for the Schizosaccharomyces pombe homologs of the Tup1/Groucho/TLE co-repressor proteins. Tup11 and Tup12. The very high level of divergence in the histone interacting repression domains of the two proteins suggested that determinants distinguishing Tup11 and Tup12 might be located in this... https://www.marcelovicente.com/product-category/styling-treatment-oil/
WD40 domain divergence is important for functional differences between the fission yeast Tup11 and Tup12 co-repressor proteins.
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