Background. Neurofibromatosis type 1 is a genetic disorder caused by loss-of-function mutations in a tumor suppressor gene (NF1) which codifies the protein neurofibromin. The frequent genetic alterations that modify neurofibromin function are deletions and insertions. https://www.spidertattooz.com/Gelish-Combo-Base-Top-Rosy-Rosita-p21103/